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Rudolph's PediatricsRudolph's Pediatrics

Section 28. Disorders of the Endocrine System > 

Chapter 538. Normal Human Sex Differentiation

Melvin M. Grumbach
Topics Discussed: endocrinology; Growth and Development; pediatric endocrinology; sex determination (analysis); sex differentiation.
Sections: Human Sex Determination, Gonadal Differentiation, Differentiation of Ducts and External Genitalia, References.
Excerpt:"Phenotypic sex is determined by a sequential process that involves the establishment of chromosomal and genetic sex in the zygote at conception, gonadogenesis and the determination of gonadal sex (sex determination), and sexual differentiation of the genital tract and external genitalia as programmed by gonadal sex.1 Divergent differentiation from the sex chromosome constitution is possible at each level of sexual organization. Table 538-1 considers the hierarchal ontogeny of sex from chromosomal sex to gender identity...."
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