Section 24. Neoplastic Disorders >
Part 2. Hematologic Malignancies >
Chapter 451. Non-Hodgkin Lymphoma
Non-Hodgkin Lymphoma: IntroductionMitchell S. Cairo and Thomas G. Gross
Topics Discussed: allopurinol; burkitt's lymphoma, childhood; large b-cell lymphoma, diffuse, childhood; large cell lymphoma, anaplastic, childhood; lymphoblastic lymphoma, childhood; lymphoma, non-hodgkin; lymphoma, non-hodgkin's, childhood; medical oncology; precursor t-cell lymphoblastic lymphoma; rasburicase; tumor lysis syndrome.
Sections: Anaplastic Large-Cell Lymphoma, Lymphoblastic Lymphoma (LL), Non-Hodgkin Lymphoma (NHL) of Immunodeficiency, References.
Excerpt:"Lymphoma represents the third most common pediatric cancer in
children between the ages of 0 to 19 years of age.1Sixty
percent of all childhood and adolescent lymphomas are classified
as non-Hodgkin lymphoma (NHL). NHL represents approximately 8% to
10% of all malignancies that occur in children between
ages 5 to 19 years. Approximately 750 to 800 cases of NHL are diagnosed
annually in children and adolescents younger than age 20 years in
the United States. Non-Hodgkin lymphoma occurs throughout childhood
and adolescence starting as early as infancy and increasing in frequency
during adolescence with a preponderance of a 3:1 male to female
ratio. The incidence of NHL in Caucasians is approximately twice
that found in African American children with approximately 9.2 versus
4.6 cases per million.2-4 Risk factors for the development
of NHL in children and adolescents are largely unknown, except that
children with either inherited and/or acquired immunodeficiencies
have a significantly increased risk for developing NHL...."
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