Chapter 438. Diagnosis and Management of Thrombosis

Janna M. Journeycake and Anthony K. C. Chan

Topics Discussed: hematology; hereditary thrombophilia; thromboembolism; thrombophilia; thrombosis.

Sections: Types of Thrombosis, Thrombophilia, Treatment, Long-Term Complications, Conclusion, References.

Excerpt:"Thrombosis, defined as excessive clotting, has three main causes: reduced blood flow (stasis), increase in blood coagulation factors (hypercoagulability), and abnormalities in the vessel wall. Once the endothelium is injured, platelet adhesion is accompanied by platelet aggregation and thrombin formation. This process is usually tightly regulated in order to prevent excessive bleeding or clotting. However, at times, the process is uncontrolled, and a thrombus can form in excessive amounts or in an unusual place, causing harm. ..."

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