Section 23. Disorders of the Blood >
Part 3. Disorders of Coagulation and Platelets >
Chapter 438. Diagnosis and Management of ThrombosisJanna M. Journeycake and Anthony K. C. Chan
Topics Discussed: hematology; hereditary thrombophilia; thromboembolism; thrombophilia; thrombosis.
Sections: Types of Thrombosis, Thrombophilia, Treatment, Long-Term Complications, Conclusion, References.
Excerpt:"Thrombosis, defined as excessive clotting,
has three main causes: reduced blood flow (stasis), increase in
blood coagulation factors (hypercoagulability), and abnormalities
in the vessel wall. Once the endothelium is injured, platelet adhesion
is accompanied by platelet aggregation and thrombin formation. This
process is usually tightly regulated in order to prevent excessive
bleeding or clotting. However, at times, the process is uncontrolled,
and a thrombus can form in excessive amounts or in an unusual place,
causing harm. ..."
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