Section 23. Disorders of the Blood >
Part 3. Disorders of Coagulation and Platelets >
Chapter 437. Acquired Coagulation DisordersGuy Young
Topics Discussed: acquired coagulation disorder; hematology; hemophilia, acquired.
Sections: Vitamin K Deficiency Bleeding, Disseminated Intravascular Coagulation, Liver Disease, Acquired Factor Deficiencies, References.
Excerpt:"Many hemorrhagic disorders in children
are caused by genetic defects, but there are also a number of important
acquired conditions that can lead to abnormal coagulation and subsequently
bleeding complications. These conditions occur in disparate clinical
situations ranging from otherwise healthy-appearing neonates to
critically ill children with multiorgan failure. The most important
of these conditions are vitamin K deficiency bleeding, coagulopathy
of liver failure, and disseminated intravascular coagulation (a
condition that can lead to both bleeding and thrombosis). Other
conditions include acquired platelet dysfunction (see Chapter 439) and acquired inhibitors to specific coagulation proteins...."
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