Section 21. Disorders of the Gastrointestinal System >
Part 5. Disorders of the Stomach and Intestine >
Chapter 409. Inflammatory Disorders of the StomachRanjan Dohil and Eric Hassall
Topics Discussed: gastric ulcer; gastritis; gastritis nsaid; gastroenterology and hepatology; helicobacter pylori; helicobacter pylori gastritis; nsaid-associated gastropathy; peptic ulcer; stomach diseases.
Sections: Historical Perspective, References.
Excerpt:"The terms acid peptic diseases, peptic diseases, or acid-related
disorders are used synonymously to describe conditions
that involve gastric acid and pepsin in their pathogenesis; they
refer to a number of disorders including esophagitis, gastritis,
peptic ulcer disease, and duodenitis. Gastritis is
a condition diagnosed histologically, not clinically or radiologically.1-5 It
is characterized by the presence of inflammatory cells and is often
found to be present in biopsies taken from gastric mucosa that appears
normal at endoscopy. Some forms of chronic, severe gastritis may
destroy mucosal elements, resulting in atrophic gastritis and intestinal
metaplasia, which in some forms may be preneoplastic. Although gastritis
and ulcer disease may occur as stand-alone entities, they are often
part of a continuum of disease.2,3,6 A special
case is that of Helicobacter pylori, an important
cause of gastritis and peptic ulcer disease discussed separately.Peptic ulcer and gastritis are uncommon in infants and young
children. Peptic disorders are far less prevalent in the pediatric
age group overall than in adults, accounting for probably no more than
10% to 20% of children seeking medical attention
for abdominal pain even in a subspecialty gastrointestinal (GI)
outpatient clinic setting.7 In adults, there has
been a profound decline in the frequency of uncomplicated peptic
ulcer disease. In contrast, there has been a relative increase in..."
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