Section 17. Infectious Diseases >
Part 4. Treatment and Prevention of Infectious Diseases >
Chapter 246. Antibacterial TherapyDavid K. Hong and Charles G. Prober
Topics Discussed: anti-bacterial agents; antibiotics; inappropriate drug prescribing; infectious diseases.
Sections: General Principles of Antibiotic Therapy, Classification of Antibiotics, Antibiotic Resistance, Use of Antibiotics in Combination, Guidance in Antibiotic Use, Specific Antibiotics, Special Issues in Pediatric Antibiotic Therapy, References.
Excerpt:"The first antibiotic to be discovered was penicillin, a natural
product of Penicillium mold. Innumerable microbial products have
been investigated since then, and much work has been done in chemically
modifying these natural products in an attempt to enhance the benefits
while minimizing the undesirable effects. These modified products, termed
semisynthetic antibiotics, increased stability and solubility, improved
pharmacokinetics (ie, wider distribution and longer half-life),
and increased antimicrobial activity. Minimizing the undesirable
effects creates antibiotics with decreased toxicity and increased
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