Topics Discussed: humoral immune defect; immunology; predominantly t-cell defect; primary immune deficiency disorder; t-lymphocyte deficiency.
Sections: Severe Combined Immunodeficiency, Primary T and Combined T and B Immunodeficiencies, Combined Immunodeficiencies Associated with Other Defects, Primary Antibody Deficiency Diseases, Disorders of Immune Regulation, References.
Excerpt:"Primary immunodeficiency diseases
result from genetic defects affecting the development and/or
the function of immune system components.1-5 They
frequently manifest soon after birth, although some become evident later
in life. Recurrent infections are the hallmark of immunodeficiency syndromes,
with the types of infections reflecting the nature of the defect. Autoimmune
disorders and certain malignancies occur more frequently in individuals
with immunodeficiency diseases...."
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