Section 5. Newborn >
Part 4. Disorders Specifically Related to Preterm Birth >
Chapter 57. Necrotizing EnterocolitisBarbara Warner
Topics Discussed: gastroenterology and hepatology; neonatal necrotizing enterocolitis; neonatology.
Sections: Pathogenesis, Genetics, Clinical Features and Differential Diagnosis, Treatment, Complications and Outcomes, Prevention, References.
Excerpt:"The incidence of NEC is reported between 0.72 and 1.1 cases per
1000 live births.1,2 Its occurrence is inversely
related to birth weight and gestational age, the most important
and consistent risk factors in its development. Preterm infants comprise
the overwhelming majority of cases, with near-term and term infants
accounting for between 5% and 25%.3,4 For
very-low-birth-weight (VLBW) infants born at less than 1500 grams,
the incidence reported from large multicenter studies ranges from
approximately 5% to 12% of VLBW live births.1,5,6 Reports
from individual institutions, however, range widely, from as low
as 0.8% to 22%.6-8 Timing of
disease onset is inversely related to gestational age, with near-term
and term infants typically developing disease in the first week
of life, while onset is more common after the first or second week for
earlier gestational ages as shown in eFigure 57.1.9..."
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