|CURRENT Diagnosis & Treatment: Pediatrics|
Chapter 28. Hematologic DisordersDaniel R. Ambruso, MD, Taru Hays, MD, Neil A. Goldenberg, MD, PhD
Sections: Bone Marrow Failure, Constitutional Aplastic Anemia (Fanconi Anemia), Acquired Aplastic Anemia, Anemias, Approach to the Child with Anemia, Pure Red Cell Aplasia, Nutritional Anemias, Anemia of Chronic Disorders, Congenital Hemolytic Anemias: Red Cell Membrane Defects, Congenital Hemolytic Anemias: Hemoglobinopathies, Congenital Hemolytic Anemias: Disorders of Red Cell Metabolism, Acquired Hemolytic Anemia, Polycythemia & Methemoglobinemia, Congenital Erythrocytosis (Familial Polycythemia), Secondary Polycythemia, Methemoglobinemia, Disorders of Leukocytes, Neutropenia, Neutrophilia, Disorders of Neutrophil Function, Lymphocytosis, Eosinophilia, Bleeding Disorders, Abnormalities of Platelet Number or Function, Inherited Bleeding Disorders, von Willebrand Disease, Acquired Bleeding Disorders, Vascular Abnormalities Associated with Bleeding, Thrombotic Disorders, Splenic Abnormalities, Splenomegaly & Hypersplenism, Asplenia & Splenectomy, Transfusion Medicine, Donor Screening & Blood Processing: Risk Management, Storage & Preservation of Blood & Blood Components, Pretransfusion Testing, Transfusion Practice, References.
Excerpt:"The normal ranges for peripheral blood counts vary significantly with age. Normal neonates show a relative polycythemia with a hematocrit concentration of 4565%. The reticulocyte count at birth is relatively high at 28%. Within the first few days of life, erythrocyte production decreases, and the values for hemoglobin and hematocrit fall to a nadir at about 68 weeks. During this period, known as physiologic anemia of infancy, normal infants have hemoglobin values as low as 10 g/dL and hematocrits as low as 30%. Thereafter, the normal values for hemoglobin and hematocrit gradually increase until adult values are reached after puberty. Premature infants can reach a nadir hemoglobin level of 78 g/dL at 810 weeks...."
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