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Neonatal Cardiology, 2eNeonatal Cardiology, 2e

Chapter 2. Regulation of Myocytecontraction and Relaxation

Topics Discussed: cardiac chronotropy; cardiac myocyte; pediatric cardiology; relaxation of cardiac muscle.
Sections: General Overview of Cellular Aspects of Cardiac Function, Structural Components Involved in Contraction and Relaxation, Excitation-Contraction Coupling, Relaxation, Contraction and Relaxation in the Immature Heart, Excitation-Contraction Coupling in Models of Congenital Heart Disease, Excitation-Contraction Coupling in Immature Human Heart, Suggested Readings.
Excerpt:"As described in Chapter 1, the developing heart undergoes a series of extremely complex processes during structural organogenesis. Considerable insight into the genetic control of these pathways has been gained in recent years. Of equal importance are the functional changes in cardiac contraction and relaxation that must accompany the morphological development of the cardiovascular system. However, much less is known about the genetic, molecular, and cellular processes that control cardiac contractile function in the mammalian heart during embryonic development and fetal maturation...."
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