Topics Discussed: drug-induced liver disease; gastroenterology and hepatology; metabolic liver disease.
Sections: Inherited Metabolic-Induced Liver Disease, Disorders of Carbohydrate Metabolism, Disorders of Lipid Metabolism, Drug-Induced Liver Disease, Nonalcoholic-Induced Liver Disease, Summary, References.
Excerpt:"Metabolic liver disease has
traditionally referred to diseases that result from inborn errors
of metabolism. These disorders are due to a single enzyme defect
that affects the synthesis or catabolism of a carbohydrate (CHO),
protein, or lipid. These defects in metabolism can result in either
liver failure or cirrhosis, with or without injury to other tissues,
or relative sparing of the liver with primary toxicity to other
organ systems (Table 28–1). Metabolic disorders that arise
in the liver with primary toxicity to other organ systems are not
addressed in this chapter. This chapter approaches metabolic-induced
liver disease not only from the traditional approach, those resulting
from a single enzyme defect, but also as a genetic susceptibility
induced by a trigger, such as a drug or a metabolic derangement
associated with visceral obesity (nonalcoholic fatty liver disease
(NAFLD))...."
The content above is only an
excerpt. For full access, log into an existing user account below, purchase an annual subscription, or
purchase a short-term subscription to the complete website.
offers pediatrics students,
educators, and practioners access to leading McGraw-Hill texts, interactive imaging
content, exclusive multimedia, and flexible curricular tools.
Timed access to all of AccessPediatrics
24 hours for $29.95
48 hours for $49.95
Or