Topics Discussed: acute illness; cyanide poisoning; cyanides.
Sections: Cyanide Poisoning: Introduction, Toxicokinetics, Pathophysiology, Clinical Presentation, Laboratory Evaluation, Treatment, Smoke Inhalation, Disposition, References.
- Cyanide poisoning causes profound tissue hypoxia.
- Poisoning causes rapid onset of central nervous system and cardiovascular toxicity.
- Helpful laboratory clues include lactic acidosis and a diminished arterialvenous O2 difference.
- Antidotal therapy with nitrites and sodium thiosulfate or with hydroxocobalamin needs to be considered early.
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