Topics Discussed: acute illness; lead; lead poisoning; lead poisoning, nervous system, childhood.
Sections: Lead Poisoning: Introduction, Sources, Pharmacokinetics/Pathophysiology, Clinical Manifestations, Management, References.
Excerpt:"
- Lead poisoning causes multisystem clinical effects: headache, abdominal pain, constipation, vomiting, clumsiness, irritability, and drowsiness.
- Laboratory evaluation may demonstrate anemia, basophilic stippling, elevated erythrocyte protoporphyrins (EP), zinc protoporphyrins (ZPP), and elevated blood lead level (BLL).
- Management requires identification and removal of the source of exposure.
- Chelation with CaNa2EDTA, BAL, or succimer is dictated by BLL and severity of symptoms.
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